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KMID : 0357220060180020047
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Journal of Korean Society Physical Therapy
2006 Volume.18 No. 2 p.47 ~ p.58
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The effects of Pulsed Ultrasound on the bone healing process in Fracture Model of Diabetes Mellitus Rat)
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Min Soon-Gyu
Chun Jin-Sung
Yong Joon-Hwan
Yoo Young-Dae
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Abstract
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Purpose: The study to pulsed ultrasound effects of diabetes mellitus fracture model in rat.
Methods: We used 36 Sprague-Dawely rats which were divided into 3 groups; the animals were divided into group of 4 rats each 4th, 14th and 28th days. All animal was induced diabetes mellitus model to used streptozotocin with 45 mg/kg. Pulsed wave were divided into $50\;mW/cm^2$ and $100\;mW/cm^2$.
Results: T-ALP value was significantly change from group II, III on 14th, 28th days (p<0.05). Especially T-ALP value to between groups was significantly change from group II on 14th days (p<0.05). Osteocalcin value was significantly change from group II on 28th days(p<0.05). At fracture site, osteoblast, osteoclast expression was observed from 4th days after treatment and it reached its maximum intensity at 28th days. At fracture site, $TGF-{\beta}_1$ expression was observed from 4th days after treatment and it reached maximum intensity at 14th days.
Conclusion: According to this study, diabetes mellitus fracture model to the more effective is divided into $50m\;W/cm^2$ pulsed ultrasound.
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KEYWORD
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Fracture healing, Diabetes mellitus, Pulsed ultrasound
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